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Shijiazhuang Kaizheng Trading Co., Ltd.

Emodin, C. I. Natural Yellow 14, 1 3 8-Trihydroxy-6-Methylanthraquinone manufacturer / supplier in China, offering Formamide (75-12-7), Sodium Hypochlorite CAS: 7681-52-9 Mf: Clnao Purity: 10%, Pharmaceutical Raw Material Methylamine Hydrochloride / Methylamine HCl CAS 593-51-1 and so on.

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Supplier Homepage Product acids Formamide (75-12-7)

Formamide (75-12-7)

Purchase Qty.:
(Tons)
1-9 10-19 20+
FOB Unit Price: US $2,300 US $2,260 US $2,200
Purchase Qty. (Tons) FOB Unit Price
1-9 US $2,300
10-19 US $2,260
20+ US $2,200
Get Latest Price
Port: Tianjin, China
Production Capacity: 5000 Tons
Payment Terms: L/C, T/T, Western Union, Paypal, Money Gram
Basic Info
  • Model NO.: 261
  • Customized: Non-Customized
  • Suitable for: Elderly
  • Purity: >98%
  • CAS Rn: 518-82-1
  • Molecular Weight: 270.24
  • Trademark: KZ
  • Specification: purity more than 98
  • HS Code: 29162000
  • Powder: No
  • Certification: GMP, ISO 9001
  • State: Solid
  • Color: White
  • Einecs: 208-258-8
  • Molecular Formula: C15h10o5
  • Transport Package: 25kg/Bag
  • Origin: China
Product Description
Product Name:Formamide
Synonyms:Amid kyseliny mravenci;amidkyselinymravenci;Formamid;Formimidic acid;formimidicacid;Formylamide;HCONH2;methanoicacid,amide
CAS:75-12-7
MF:CH3NO
MW:45.04
EINECS:200-842-0
Product Categories:FM - FZAnalytical Standards;Alphabetical Listings;E-FAlphabetic;F;NMR Reference Standards;NMRStable Isotopes;Spectroscopy;Stable Isotopes;FM - FZ;ACS Grade;Alphabetic;Amber Glass Bottles;Analytical Reagents;Analytical Reagents for General Use;Analytical Standards;Analytical/Chromatography;E-L;Histological Solvents;Puriss p.a.;Puriss p.a. ACS;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;Acids and Bases;ACS and Reagent Grade Solvents;ACS Grade Solvents;Amides;Biochemicals and Reagents;Building Blocks;C2 to C7;Carbon Steel Cans with NPT Threads;Carbonyl Compounds;Chemical Synthesis;Denaturation;Organic Building Blocks;Semi-Bulk Solvents;NMR;Spectrophotometric Grade;Spectrophotometric Solvents;Spectroscopy Solvents (IR;UV/Vis);Organic solvents
Mol File:75-12-7.mol
 
 
Formamide Chemical Properties
mp 2-3 °C(lit.)
bp 210 °C(lit.)
density 1.134 g/mL at 25 °C(lit.)
vapor density 1.55 (vs air)
vapor pressure 0.08 mm Hg ( 20 °C)
refractive index n20/D 1.447(lit.)
Fp 310 °F
storage temp. 2-8°C
solubility H2O: 10 M at 20 °C, clear, colorless
form liquid
color clear, colorless
Water Solubility miscible
Sensitive Hygroscopic
Merck 14,4237
CAS DataBase Reference75-12-7(CAS DataBase Reference)
NIST Chemistry ReferenceFormamide(75-12-7)
EPA Substance Registry SystemFormamide(75-12-7)
 
Safety Information
Hazard Codes T
Risk Statements 61-41-37/38-48/22-40
Safety Statements 53-45-36/37/39-26-23-36/37
WGK Germany 2
RTECS LQ0525000
10
HS Code 29241900
HS Code 29309070
Hazardous Substances Data75-12-7(Hazardous Substances Data)
 
MSDS Information
ProviderLanguage
FormamideEnglish
SigmaAldrichEnglish
ACROSEnglish
ALFAEnglish
 
Formamide Usage And Synthesis
Chemical PropertiesIt is colorless, odorless and oily liquid with slight ammonia-odor when containing impurities. It has hygroscopicity property. It has a relative molecular mass of 45.04. It has the relative density being 1.1334, the melting point being 2.55 ºC, the boiling point being 210.5 ºC, the refractive index being 1.4475, the flash point being 154 ºC and the viscosity being 3.76mPa • s (20 ºC). It is insoluble in ether and chlorinated solvents, slightly soluble in benzene and is miscible with water, methanol, ethanol, , ethylene glycol, phenol and low grade ester. This product can dissolve the casein but does not dissolve albumin. This product can dissolve casein, dextrose, corn protein, gelatin, glue, resin, starch, lignin, cellulose acetate, nylon, and some inorganic salts: the chloride compounds of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel and also some kinds of sulfates and nitrates. At room temperature, formamide has a low hydrolysis rate. Formamide contains two active functional groups, namely the carbonyl and amide groups. It is easy to have chemical reaction to produce a lot of nitrogen-containing heterocyclic compound.  In the presence of a catalyst, it can react with organic halide or alcohol to form formic esters. This product can also react with β-diketone, β-imino ketone, aliphatic acyloin, arene acyloin as well as heterocyclic acyloin. It can react with phosphorus pentasulfide to generate sulfur formamide. Formamide has strong corrosion effect on copper, brass, lead and rubber, therefore the storage and transportation should be paid attention. 
The main purposes: formamide can be used as the softener and solvent of animal glue and paper. It can also be used as the solvent of the spinning of the acrylonitrile copolymer, the polymerization of unsaturated amine polymerization and the production of pharmaceuticals as well as the solvent for extraction of grease and the dissolving items mentioned above. As intermediates, it can be applied the synthesis of imidazole, pyrimidine, 1, 3, 5-triazine, 
The above information is edited by the chemicalbook of Dai Xiongfeng.
Acute toxicityThe LD50 for rat via stomach is 6.1g / kg and for mice is 3.15g / kg. Acute symptoms is characterized by the injury of the nervous system, accompanied with conjunctivitis and respiratory disorders, straight convulsions and the final death after 3 to 4 days. The threshold concentration for chronic inhalation effects was 6 ± 4mg / m3. For the maximum allowable concentration for operating environment: for United States, the value is 30 mg/m3 (20 ppm) while the value is 3 mg/m3 (vapor, absorbed through the skin) for Soviet Union.
Chemical PropertiesIt is transparent oily liquid with slight ammonia smell. It has hygroscopic property. It is miscible with water and ethanol, slightly soluble in benzene, chloroform and ether.
Chemical PropertiesIt is transparent oily liquid with slight ammonia smell. It has hygroscopic property. It is miscible with water and ethanol, slightly soluble in benzene, chloroform and ether.
Application  
Formamide has active reactive and special dissolving capability. It can be used as the raw material for organic synthesis, paper processing agents, softening agent of fiber industry and animal glue as well as being used as the analytical reagent for measuring the amino acid content of rice. In the field of organic synthesis, it has most application in medicine as well as a lot of applications in other fields such as pesticides, dyes, pigments, fragrances and additives. It is also a kind of excellent organic solvent and is mainly applied to the spinning of acrylonitrile copolymers and ion exchange resins and plastics antistatic coating or conductive coating. In addition, it can also be used for separating chlorosilane and purifying grease. Formamide can have various kinds of reactions, in addition to have its three hydrogen atoms participate in the reaction, can also be subject to dehydration, CO removal, the introduction of an amino group, an acyl group and cyclization reaction. Take cyclization as an example, diethyl malonate can have cyclization reaction with formamide to generate the intermediate of vitamin B4, the 4, 6-dihydroxypyrimidine. O-aminobenzoic acid can have cyclization reaction with formamide to generate the quinazolinone-4 which is the intermediate for the synthesis of antiarrhythmic drug phenantrolihne. 3--amino-4-ethoxycarbonyl-pyrazole can have cyclization reaction with formamide to generate the inhibitor of the xanthine oxidase, EDTA can have cyclization reaction with formamide to give anti-cancer drugs ethylenediamine. Methyl ethyl methoxymalonate can have cyclization reaction with formamide to generate the intermediate of sulfonamide drug, 5-methoxy-4, 6-dihydroxy pyrimidine disodium.
It can be used as analytical reagents, solvents and softening agents as well as being used in organic synthesis.
It can be applied to medicine and pesticide industry.
Production method1. One-Step method: the first step is through the reaction of carbon monoxide and methanol for generating methyl formate in the presence of sodium methoxide. The second step: the methyl formate is further subject to aminolysis for generation of formamide with the reaction conditions being 80-100 ºC and 0.2-0.6 MPa. This method has relative problems. 2. The method of formic acid; the formic acid first has esterification reaction with methanol to generate methyl formate which undergoes aminolysis to generate formamide with the separation of methanol and impurities through distillation to obtain the final product. Owing to its high cost, this method has been gradually eliminated. 3. One Step method: this is via the reaction of carbon monoxide and ammonia for the direct synthesis of formamide in high pressure (10-30 MPa) and a temperature of 80-100 ºC with the sodium methylate as the catalyst. 4. The formic acid and urea method. 5. The new method has sodium and ammonium salts for reaction to generate formamide at a certain temperature and pressure. This method has already applied domestic invention patent.
CategoryToxic substances.
Toxicity gradingPoisoning
Acute toxicityOral- rat LD50: 5577 mg / kg; Oral - Mouse LD50: 3150 mg/kg.
Irritation dataEye-rabbit 100 mg severe.
Flammability and hazardous characteristicsFlammable with fire releasing toxic nitric oxide gas.
Storage propertiesWarehouse: cold, ventilation, dry.
Extinguishing MediaCarbon dioxide, dry chemical powder.
Professional standardsTWA 15 mg / m³; STEL 45 mg / m3
Chemical PropertiesClear, colorless liquid
UsageFormamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.
General DescriptionA colorless liquid with a faint odor of ammonia. Denser than water. Freezing point 36°F.
Air & Water ReactionsHygroscopic. Water soluble.
Reactivity ProfileFormamide is incompatible with strong oxidizers, acids and bases. Sensitive to light. Reacts with water very slowly at room temperature, but rate is accelerated by acids and bases at elevated temperatures. Incompatible with iodine, pyridine and sulfur trioxide. Reacts explosively with furfuryl alcohol, H2O2, Tl(NO3)3.H2O, nitromethane and P2O5. An effective solvent: dissolves casein, glucose, tannins, starch, lignin, polyvinyl alcohol, cellulose acetate, nylon, the chlorides of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel, the acetates of the alkali metals, some inorganic sulfates and nitrates. Attacks copper and brass .
Health HazardINHALATION: A moderate irritant to mucous membranes. EYES: Moderately irritating to the eyes. SKIN: A mild to moderate irritant to the skin.
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